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  • Title: Altered serum gastrin levels in achlorhydric states.
    Author: Turnipseed WD, Keith LM.
    Journal: Am J Surg; 1976 Feb; 131(2):175-7. PubMed ID: 1251959.
    Abstract:
    Hypergastrinemia occurs in achlorhydric states if the antrum is not diseased, and evidence has been presented that suggests that antral gastritis diminishes gastrin levels in achlorhydric patients. There is a dramatic gastrin response to calcium challenge in patients with pernicious anemia. Only minimal response was observed in patients with atrophic gastritis. Unlike the response observed in the Zollinger-Ellison syndrome, secretin challenge suppresses gastrin in achlorhydric states. These findings add a new dimension to the utility of serum gastrin determinations.
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