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  • Title: A supercritical fluid-based coating technology. 3: preparation and characterization of bovine serum albumin particles coated with lipids.
    Author: Ribeiro Dos Santos I, Richard J, Thies C, Pech B, Benoit JP.
    Journal: J Microencapsul; 2003; 20(1):110-28. PubMed ID: 12519706.
    Abstract:
    Solvent-free microparticles, loaded with bovine serum albumin as a model protein, were produced using a novel supercritical (SC) fluid-based coating technology. Coating material consists either of trimyristin (Dynasan 114) or of Gelucire 50-02. Microparticles obtained were characterized as regards their morphology, protein content and in vitro release profile. A discontinuous coating made of micro-needles of trimyristin led to an initial burst release of approximately 70% in 30 min. However, a prolonged release of the BSA could be achieved in a phosphate buffer solution at 37 degrees C over a 24 h period from particles coated with Gelucire 50-02. Furthermore, it was shown that BSA does not undergo any degradation after SC CO(2) treatment under the conditions used in the coating process.
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