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  • Title: Cellular immune mechanisms in autoimmune thrombocytopenic purpura: An update.
    Author: Coopamah MD, Garvey MB, Freedman J, Semple JW.
    Journal: Transfus Med Rev; 2003 Jan; 17(1):69-80. PubMed ID: 12522773.
    Abstract:
    Autoimmune thrombocytopenic purpura (AITP) is a bleeding disorder in which autoantibodies are directed against an individual's own platelets, leading to enhanced clearance through Fc receptor (R)-mediated phagocytosis by macrophages residing in the reticuloendothelial system (RES), particularly in the spleen. The production of IgG autoantibodies is critically dependent on cellular immune mechanisms particularly relating to T cells. We review the recent literature of the cell-mediated immunology of AITP focusing on platelet phenotype, genetics, T-cell reactivities, and cytokine profiles in patients with AITP. Understanding the interaction between these cell-mediated mechanisms is vital for developing antigen specific immunotherapies to treat this autoimmune disease.
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