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  • Title: Administration of bisphosphonate prevents disuse bone atrophy induced by tail suspension.
    Author: Kurokouchi K, Ito T, Ohmori S, Kanda K, Murata Y, Yasukawa K, Izumi R, Inazu M, Iwata H, Seo H.
    Journal: Environ Med; 1997 Oct; 41(1):16-7. PubMed ID: 12523373.
    Abstract:
    We recently demonstrated that osteopenia induced by rat tail-suspension was associated with an initial increase in bone resorption. To study the significance of the increase in early bone resorption for osteopenia, we investigated whether administration of YH529, a third-generation bisphosphonate, prevents the development of osteopenia as evidenced by increased wet weight of the femur, together with its calcium and phosphorus contents, when compared with those of tail-suspended rats treated with the vehicle alone. These results suggested that the initial increase in bone resorption plays an important role in the development of osteopenia induced by tail suspension.
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