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  • Title: [Studies on the metabolism of gentiopicroside by rat intestinal flora].
    Author: Yang XF, Song CQ.
    Journal: Zhongguo Zhong Yao Za Zhi; 2000 Nov; 25(11):673-6. PubMed ID: 12525070.
    Abstract:
    OBJECTIVE: To study the metabolism of gentiopicroside by rat intestinal flora in vitro and time profiles of gentiopicroside and its metabolites in rat serum after oral administration of gentiopicroside. METHOD: Using high performance liquid chromatography (HPLC) for determination of gentiopicroside, gentianine and gentianal content of rat intestinal flora culture medium in vitro and rat serum sample in vivo. RESULT: Gentiopicroside was metabolized quickly in vitro by rat intestinal flora, consequently gentianine and gentianal content appeared. Gentianine and gentianal were observed after gentiopicroside oral administration 4 times in rat serum sample, and gentiopicroside content decreased after oral administration 6 times. CONCLUSION: Gentianine and gentianal were the important bioactive metabolites of gentiopicroside in rats.
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