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  • Title: [Expression of mucin MUC1 and MUC2 in colorectal carcinoma and their clinical significance].
    Author: Huang WB, Shi LH, Zhu XQ, Xu GX, Qi Q.
    Journal: Ai Zheng; 2002 Nov; 21(11):1231-4. PubMed ID: 12526222.
    Abstract:
    BACKGROUND & OBJECTIVE: The up-regulation of mucin MUC1 expression or down-regulation of mucin MUC2 expression may be involved in carcinogenesis of some neoplasms, but there was few report about the relationship between mucin MUC1 and MUC2 expression and Chinese colorectal carcinoma. The aim of this study was to explore relationship between expression of mucin MUC1 and MUC2 in colorectal carcinoma and clinicopathological parameters and their clinical significance. METHODS: The expression of mucin MUC1 and MUC2 in 126 cases of colorectal carcinoma were detected by S-P immunohistochemical technique. RESULTS: The positive expression rates of mucin MUC1 and MUC2 in normal colorectal mucosa were 0 and 100%, respectively, but the positive expression rates of mucin MUC1 and MUC2 in 126 cases of colorectal carcinoma were 42.1% and 36.5%, respectively (P < 0.01); the expression of mucin MUC1 was positive correlated to the depth of invasion, lymph node metastasis, and Dukes staging (P < 0.05), but negative correlated to the degree of differentiation (P < 0.05); mucin MUC2 expression was related to invasion, lymph node metastasis, and Dukes staging (P < 0.05), but unrelated to differentiation (P > 0.05). CONCLUSIONS: The up-regulation of mucin MUC1 expression or down-regulation of mucin MUC2 expression may be involved in carcinogenesis and progression in colorectal carcinoma, and the detecting of mucin MUC1 and MUC2 may be predicting its prognosis in colorectal carcinoma.
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