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  • Title: [Preparation of famotidine microemulsion and its quality evaluation].
    Author: Ye HY, Zhang ZY, Gao S, Lu Y, Wang Y.
    Journal: Di Yi Jun Yi Da Xue Xue Bao; 2003 Jan; 23(1):68-70. PubMed ID: 12527522.
    Abstract:
    OBJECTIVE: To study the preparation of famotidine microemulsion (FM) and its quality evaluation, thereby to establish the quality-control criteria for this preparation. METHODS: The formulations of the FM were optimized by studying the pseudoternary phase diagrams and its absorption in rat jejunum using in situ perfusion method. The morphology, particle size distribution, famotidine concentration and stability of the FM were studied. RESULTS: The optimization of formulation was completed successfully. Electron microscopy presented the FM as small spherical drops, with a mean diameter of 65 nm. The average recovery as determined by high-performance liquid chromatography was 97.63%, its mean RSD being 0.72%. CONCLUSION: The FM is easy to prepare with consistent quality, whose reliable determination method may be easily reproduced.
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