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  • Title: Zinc and copper complexes of prodigiosin: implications for copper-mediated double-strand DNA cleavage.
    Author: Park G, Tomlinson JT, Melvin MS, Wright MW, Day CS, Manderville RA.
    Journal: Org Lett; 2003 Jan 23; 5(2):113-6. PubMed ID: 12529118.
    Abstract:
    [reaction: see text] Zinc(II) and copper(II) complexes of prodigiosin (1) have been characterized. All N-atoms of 1 bind Cu(II) to generate 5: the complex exhibits regiospecific oxidation of the C-pyrrole. In contrast, coordination by Zn(II) to 1 produces Zn(1)(2) (8), a 4-coordinate tetrahedral complex. The influence of these binding geometries on Cu-mediated double-strand (ds) DNA cleavage by 1 is discussed.
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