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  • Title: Glutathione S-transferase (GSTM1 and GSTT1)-dependent risk for colorectal cancer.
    Author: Laso N, Lafuente MJ, Mas S, Trias M, Ascaso C, Molina R, Ballesta A, Rodriguez F, Lafuente A.
    Journal: Anticancer Res; 2002; 22(6A):3399-403. PubMed ID: 12530094.
    Abstract:
    BACKGROUND: The deleted GSTT1 and GSTM1 genotypes (null genotypes) resulting in loss of transferase activity are found in 10-20% and 50-60% of the population, respectively. PATIENTS AND METHODS: The GSTT1- and GSTM1-dependent risk for sporadic colorectal cancer (CRC) was studied in 247 incident CRC cases and 296 hospital-based controls. RESULTS: The GSTT1-null genotype was found to be 1.5 times more prevalent in CRC patients (17.4%) compared with controls (11.1%) (crude OR 1.6; p = 0.03). The GSTM1-null genotype was found to be equally prevalent in cases and controls (53%). Multivariate analysis showed a significant 1.7-fold risk for CRC associated with the GSTT1-null genotypes (p = 0.04) and this increased to 2.9 for smokers (p = 0.02). CONCLUSION: This study provides evidence of gene-environment interaction and illustrates the importance of further research into the role of genetic susceptibility for CRC.
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