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  • Title: Cerebral hemoglobin concentration and oxygen saturation measured by intensity modulated optical spectroscopy in the human fetus during labor.
    Author: Chipchase J, Kirkby D, Peebles D, Cope M, Rodeck C.
    Journal: J Perinat Med; 2002; 30(6):502-9. PubMed ID: 12530107.
    Abstract:
    AIMS: To quantify hemoglobin concentration and oxygen saturation in the human fetal brain using intensity modulated optical spectroscopy during labor. METHODS: A specially designed probe was applied to the fetal scalp in 20 women during uncomplicated labor at term. Optical fibres transmitted near infra-red light to and from an intensity modulated optical spectrometer (IMOS), which detected changes in the optical parameters of the infra-red light source. Using novel off-line analytic techniques, these changes were converted into absolute measurements of oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb). Summing Hb and HbO2 gives total hemoglobin concentration (HbT) and HbO2/HbT x 100% provided measurements of cerebral saturation (SmcO2). RESULTS: Of 20 fetuses studied, data from 10 fetuses were suitable for analysis. Over three consecutive uterine contractions, the mean (+/- SD) absolute cerebral concentrations of Hb and HbO2 were 30 +/- 18 and 46 +/- 21 mumol/l, respectively. This gave a mean cerebral HbT of 77 +/- 29 mumol/l and a mean SmcO2 of 59 +/- 12%. In the other ten fetuses insufficient light was detected to allow chromophore quantification. CONCLUSION: These are the first absolute measurements of cerebral Hb and HbO2 in human fetuses during labor. The values of total hemoglobin are similar to those obtained in neonates with hypoxia-ischemia and the measurements of fetal cerebral oxygen saturation are similar to previously published values.
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