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  • Title: [Advances in the study of mechanisms of the tumor angiogenesis inhibitors].
    Author: Xiao D, Ding J.
    Journal: Sheng Li Ke Xue Jin Zhan; 1999 Jul; 30(3):219-23. PubMed ID: 12532783.
    Abstract:
    Tumor angiogenesis inhibitor is the drugs which can destroy or inhibit neovascularization, and block the growth and metastasis of cancer. For clinical applications it may be useful to divide the antiangiogenic drugs into two categories: class 1(specific inhibitors) and class 2 (non-specific inhibitors). This review intends to provide the recent progress of the mechanisms of antiangiogenic drugs (1) Regulation of angiogenesis growth factors; (2) Inhibition of basement membrane degradation; (3) Mediating signal transduction pathway; (4) Effect of cell cycle; (5) Regulation of tumor-related gene.
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