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  • Title: Photoprotective activity of melanin preparations in human skin exposed to UV irradiation: dependence on previous photoexposure.
    Author: Paramonov BA, Turkovskii II, Potokin IL, Yurlova NA, Chebotarev VY.
    Journal: Bull Exp Biol Med; 2002 Oct; 134(4):366-9. PubMed ID: 12533761.
    Abstract:
    Photoprotective effects of three melanin preparations (from black yeast fungi and Sepia sp.) were studied. These preparations in aqueous solutions (5 g/ml, dark exposure for 7 days) demonstrated high photomodification capacity upon exposure to visible light in doses of up to 1.8 kJ/m2. Preliminary exposure of these solutions to visible light in a dose of 360 kJ/m2 notably decreased the photoprotective effect of melanins during UV exposure of the skin treated with these solutions (at UV dose of 3.4 kJ/m2). This necessitates empirical selection of the dose and storage condition of melanin preparations for attaining the optimal photoprotective effect.
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