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  • Title: [Research of ultra-structural pathological changes of nervous, endocrine and immune system in heroin addicts].
    Author: Li LH, Yao H, Zhao YH, Zhu H, Xing YM, Feng ZT, Yang RX.
    Journal: Fa Yi Xue Za Zhi; 2001 Aug; 17(3):145-7. PubMed ID: 12533895.
    Abstract:
    OBJECTIVE: To investigate ultrastructural pathological changes of Heroin-Addicts. METHODS: Heroin-Addicts' central nervous system, endocrine system, immune system and reproductive system in 4 cases are observed by using transmission electron microscope(TEM). RESULTS: The changes of central nervous system are mitochondrion swelling, crista fragmentation and disappear. Endoplasmic reticulum dilation, nervous fibres and cell organelles reduction; mitochondrion swelling, Partial crista fragmentation and endoplasmic reticulum dilation are also found in endocrine system; Lymphocytes reduction, cytoplasm ingredient reduction and dead lymphocytes increase in immune system; in reproductive system, spermatogenic cells and cell organelles are reduced in the male and follicle disappeared in the female. CONCLUSION: Ultra-structural pathological changes of heroin-addicts are presented acute, chronic oxygen deficiency degeneration and necrosis.
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