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  • Title: [Study on p53 gene expression following transient ischemia in the gerbil].
    Author: Gu WP, Yang QD, Xie GJ.
    Journal: Hunan Yi Ke Da Xue Xue Bao; 2001 Apr 28; 26(2):121-2. PubMed ID: 12536640.
    Abstract:
    OBJECTIVE: To study the expression of p53 gene after transient ischemia in the gerbil. METHODS: Northern blot was used to detect the expression of the p53 mRNA in the forebrain during different periods after post-ischemic reperfusion in the gerbil. RESULTS: The expression of p53 mRNA increased in the forebrain during the 6th hour to the 3rd day of reperfusion following 6 min of ischemia (P < 0.05). CONCLUSION: The high level expression of p53 might induce neuronal apoptosis after ischemia.
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