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  • Title: Mitogen-activated protein kinases and their role in regulation of cellular processes.
    Author: Strnisková M, Barancík M, Ravingerová T.
    Journal: Gen Physiol Biophys; 2002 Sep; 21(3):231-55. PubMed ID: 12537349.
    Abstract:
    Mitogen-activated protein kinases (MAPKs) are evolutionary conserved enzymes connecting cell-surface receptors to critical regulatory targets within cells. The three major MAPK cascades are known, the extracellular signal-regulated protein kinase (ERK) cascade, c-Jun amino-terminal protein kinase/stress-activated protein kinase (JNK/SAPK) cascade and p38-MAPK cascade. This paper is focused on characterization of these MAPK cascades in terms of their distribution and biological role in some pathological processes (apoptosis, hypertrophy) with a special orientation on the role of MAPKs in cardiovascular system during ischemia/reperfusion.
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