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  • Title: [Effects of two growth factors combination on the proliferation and differentiation of human osteoblast-like cells].
    Author: Tian W, Wang D, Qiao J, Chen W.
    Journal: Hua Xi Kou Qiang Yi Xue Za Zhi; 1999 Feb; 17(1):78-81. PubMed ID: 12539332.
    Abstract:
    OBJECTIVE: To examine the effects of platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF), insulin-like growth factor (IGF-II) and type beta transforming growth factor(TGF-beta) which were believed to have biological effects on bone cells on human osteoblast-like cells. METHODS: 3H-TdR, 3H-Proline and alkaline phosphatase of the osteoblast-like cells were tested to study the combinating effects of different growth factors on the proliferation and differentiation of osteoblast-like cells. RESULTS: The combination of different growth factors had promotive effect and synergic interact on proliferation and differentiation of osteoblast-like cells. CONCLUSION: The phenomena indicate that the combination of two growth factors will enhance the biological effects of bone formation.
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