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  • Title: [Telomerase hTRT mRNA expression in oral squamous cell carcinogenesis].
    Author: Zhang L, Zhang W, Liu Z.
    Journal: Hua Xi Kou Qiang Yi Xue Za Zhi; 1999 Nov; 17(4):307-9. PubMed ID: 12539372.
    Abstract:
    OBJECTIVE: To investigate the relationship between telomerase hTRT gene expression and malignant development of oral mucosa epithelium. METHODS: 82 cases were detected by in situ hybridization technique for hTRT gene, including 7 cases of normal oral mucosa, 7 cases of hyperplasia lesions, 30 case sof oral precancerous lesions (dysplasia lesion), 8 cases of oral mucosa carcinoma in situ and 30 cases of oral squamous cell carcinomas. RESULTS: 1. Weaker expression of hTRT mRNA was observed in normal oral mucosa and hyperplasia lesions. Positive cells were present in basal layer and parabasal layer, and hTRT positivity was 21.4% (3 of 14). 2. The expression of hTRT mRNA in the precancerous lesions was gradually strong associated with phenotypic progression and the degree of dysplasia. Positive cell extended to multi-layered epithelium, and hTRT positivity was 46.7% (14 of 30). 3. Strong hTRT mRNA expression was observed in squamous cell carcinoma, and the positivity was 81.6% (31 of 38). CONCLUSION: Telomerase hTRT gene expression is closely related to the malignant degree of oral mucosa, the reactivated telomerase may play a crucial role in the progression of oral cancer.
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