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  • Title: [The effects of MMPs and TIMPs on the metastasis of oral squamous cell carcinoma to neck lymph nodes].
    Author: Liu G, Li J, Li Z, Chen X.
    Journal: Hua Xi Kou Qiang Yi Xue Za Zhi; 2001 Aug; 19(4):216-8, 224. PubMed ID: 12539723.
    Abstract:
    OBJECTIVE: This study is aim at investigating the relationship between the expression and activity of MMP-2,9, TIMP-1,2 and the metastasis of oral squamous cell carcinoma to neck lymph node. METHODS: The expression of MMP-2,9, TIMP-1,2 in 30 oral squamous cell carcinoma, two oral squamous cell carcinoma cell lines GNM and TSCCa was detected by in situ hybridization; Zomography was performed to determined the activity of MMP-2,9 in cancer tissue and conditioned medium of GNM and TSCCa; Ability of invasion of GNM and TSCCa was measured with in vitro invasion assays. RESULTS: Both tumor cells and stroma expressed both MMP-2,9 and TIMP-1,2; It was found that MMP-2,9, TIMP-1,2 had a higher expression in patients with neck lymph node metastasis than those without metastasis (P < 0.05), positive percentage of MMP-2,9 in GNM was higher than that in TSCCa; The MMP-2,9 in node-positive patients was more active than in node-negative ones (P < 0.05); GNM had more active MMP-2, 9 and higher invasive potential than TSCCa. CONCLUSION: MMP-2,9 may play an important role in metastasis of oral squamous cell carcinoma; Elevation of TIMP-1,2 is likely to be the result of interaction of tumor and stroma.
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