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  • Title: Ketones as building blocks for dynamic combinatorial libraries: highly active neuraminidase inhibitors generated via selection pressure of the biological target.
    Author: Hochgürtel M, Biesinger R, Kroth H, Piecha D, Hofmann MW, Krause S, Schaaf O, Nicolau C, Eliseev AV.
    Journal: J Med Chem; 2003 Jan 30; 46(3):356-8. PubMed ID: 12540234.
    Abstract:
    New and potent inhibitors of neuraminidase, a key enzyme in the influenza virus activity, have been discovered in dynamic combinatorial libraries based on ketones and amines as building blocks. Selective synthesis of a number of inhibitors among multiple theoretically possible combinations of building blocks is driven by the presence of the target enzyme.
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