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  • Title: [Evaluation of 99mTc(V)-DMSA imaging in patients with pharyngolaryngeal carcinoma].
    Author: An R, Bender H, Gurke M, Biersack HJ.
    Journal: Lin Chuang Er Bi Yan Hou Ke Za Zhi; 1999 Dec; 13(12):562-4. PubMed ID: 12541429.
    Abstract:
    OBJECTIVE: To evaluate the value of tumor-seeking agent 99mTc(V)-DMSA in patients with pharyngolaryngeal carcinoma and its biodistribution in human being. METHOD: Planar and SPECT scintigraphy with 99mTc(V)-DMSA were performed in 12 patients with histologically confirmed pharyngolaryngeal carcinoma. The dynamic distribution in patients was also analyzed. RESULT: 9 cases (11 lesions) showed increased uptake by planar imaging and 11 cases (19 lesions) were clearly demonstrated by SPECT images. Furthermore, distant metastatic lesions were showed in 5 patients. Biodistribution in patients showed the accumulation of 99mTc(V)-DMSA in kidney was significantly greater than other organs. CONCLUSION: These results could suggested the clinical utility of 99mTc(V)-DMSA, specially with SPECT, for detecting primary pharyngolaryngealcarcinoma and their metastatic lesions (both local and distant). 99mTc(V)-DMSA Tumor-seeking agent Pharyngolaryngeal carcinoma.
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