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  • Title: [Determination of the point of gene mutation in two types of tissue from the aminoglycoside antibiotics induced deaf patients].
    Author: Xu L, Chen W, Xing C.
    Journal: Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2001 Apr; 15(4):149-51. PubMed ID: 12541634.
    Abstract:
    OBJECTIVE: To elucidate the gene mutation presents in hair follicle cells, just as blood cells, in the aminoglycoside antibiotics induced deaf patients(AAID). METHOD: Mitochondrial DNA of blood cells and/or hair follicle cells from 8 members of 3 aminoglycoside antibiotics induced deafness families were analysed using PCR-SSCP and Alw 26 I digestian. RESULT: Our result showed that a gene mutation at nucleotide 1555 in 12 S rRNA of mitochondrial DNA appeared in blood cells and/or hair follicle cells of 7 subjects among those 8 members. Only a father with normal hearing did't exhibit such a mutation. CONCLUSION: This indicated that hairs could be used as a sample instead of blood to perform gene examination for AAID.
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