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  • Title: [The study of TNF-alpha destructive action to the bone in human middle cholesteatoma].
    Author: Xue Q, Jin K, Song H.
    Journal: Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2001 Jan; 15(1):13-4. PubMed ID: 12541874.
    Abstract:
    OBJECTIVE: To study the expression of TNF-alpha in the cholesteatoma and elucidate the role of TNF-alpha in the destruction of bone. METHOD: All samples (5 microns paraffin sections) from 25 cholesteatoma cases and 10 normal cases were examined by immunohistochemical SABC method and analysed by computer image. RESULT: In 25 cholesteatoma cases, TNF-alpha expressed in the cytoplasm of the full epithelial tissue cells, subcutaneous inflammatory cells and fibroblast. In contrast, the normal cases, there were 6 cases week positive, 4 cases negative. The results of the computer image quantitative analysis system showed that the mean optical density of TNF-alpha was 0.1326 +/- 0.0022 in the cholesteatoma epithelial tissue and 0.0868 +/- 0.0014 in normal skin epithelial tissue respectively, both of which had significantly differentiation (P < 0.05). CONCLUSION: TNF-alpha may be a factor of the destruction of bone of cholesteatoma.
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