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  • Title: Antitumor agents. 221.1 buceracidins A and B, two new flavanones from Bucida buceras.
    Author: Hayashi K, Nakanishi Y, Bastow KF, Cragg G, Nozaki H, Lee KH.
    Journal: J Nat Prod; 2003 Jan; 66(1):125-7. PubMed ID: 12542360.
    Abstract:
    As part of a study on antitumor agents from rainforest plants, two new flavanones, buceracidin A (1), 5,2'-dihydroxy-3-methoxy-6,7-(2' ',2' '-dimethylchromene)flavanone, and buceracidin B (2), 5,2'-dihydroxy-6,7-(2' ',2' '-dimethylchromene)flavanone, were isolated together with four known prenylated flavanones, minimiflorin (3), 3-hydroxyminimiflorin (4), 3-methoxyminimiflorin (5), and mundulinol (6), from Bucida buceras. The structures of buceracidins A and B were elucidated from detailed 2D NMR analyses. Among the six flavanones, 3, 5, and 6 were marginally cytotoxic in a human tumor cell line panel.
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