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  • Title: Separation of albendazole sulfoxide enantiomers by chiral supercritical-fluid chromatography.
    Author: del Nozal MJ, Toribio L, Bernal JL, Nieto EM, Jiménez JJ.
    Journal: J Biochem Biophys Methods; 2002 Dec 31; 54(1-3):339-45. PubMed ID: 12543509.
    Abstract:
    The enantioseparation of albendazole sulfoxide (ABZSO) by chiral supercritical-fluid chromatography (SFC) on two columns, based on the polysaccharide derivatives Chiralpak AD and Chiralcel OD, was studied. The effect of different modifiers, methanol, ethanol, 2-propanol, and acetonitrile, was examined. The results showed that ABZSO can be separated on both columns, using an alcohol-type modifier. Using the Chiralpak AD column, the best results were obtained with 2-propanol and, in the case of the Chiralcel OD, with methanol.
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