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  • Title: [Correlation between serum alpha-fetoprotein variant levels in patients with hepatocellular carcinoma and the presence of alpha-fetoprotein mRNA in the circulating blood].
    Author: Kang XY, Yin ZF, Qian HH, Wu ZD, Yu ZX, Wu MC.
    Journal: Zhonghua Gan Zang Bing Za Zhi; 2003 Jan; 11(1):17-9. PubMed ID: 12546734.
    Abstract:
    OBJECTIVE: To investigate the relationship between serum alpha-fetoprotein (AFP) variant levels in patients with hepatocellular carcinoma (HCC) and cancer cells disseminating through blood. METHODS: Serum AFP variant levels were measured by crossed immunoaffino-electrophoresis in the presence of lectin before initial surgical treatment in HCC patients. Circulating tumor cells were simultaneously detected in pre-operative blood samples using reverse transcription-polymerase chain reaction (RT-PCR) for AFP mRNA. RESULTS: Forty-six HCC patients with serum AFP positive were studied. Serum AFP variant level > or 20% was showed in 37 patients, among whom there were 22 (59.5%) showing AFP mRNA positive. In contrast, the positive AFP mRNA expression was only observed in 2 out of 9 patients (22.2%) with AFP variant level<20% (x(2)=4.02, P<0.05). CONCLUSION: In hepatocellular carcinoma patients, increased AFP variant levels are associated with a haematogenous spread of tumor cells.
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