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  • Title: Nonsuppressible insulin-like activity of human serum. A potent inhibitor of insulin degradation.
    Author: Kahn CR, Megyesi K, Roth J.
    Journal: J Clin Invest; 1976 Feb; 57(2):526-9. PubMed ID: 1254732.
    Abstract:
    Nonsuppressible insulin-like activity soluble in acid ethanol (NSILA-s) is a well-characterized peptide derived from human serum which has previously been shown to have insulin-like bioactivity and react with both insulin and NSILA-s receptor sites in liver plasma membranes. In the present study we find that NSILA-s is also a potent competitive inhibitor of the insulin-degrading system of the liver plasma membrane. The most purified NSILA-s preparation tested was 20-fold more potent than insulin itself, and significant inhibition of insulin degradation occurred at concentrations of NSILA-s similar to those found in plasma.
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