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  • Title: Separate Fc-receptors for immunoglogulins IgG2a and IgG2b on an established cell line of mouse macrophages.
    Author: Walker WS.
    Journal: J Immunol; 1976 Apr; 116(4):911-4. PubMed ID: 1254971.
    Abstract:
    The specificity of Fe-receptors on IC-21 cells, an established line of mouse peritoneal macrophages with antibody-dependent effector cell activity has been examined. Only IgG2a and IgG2b myeloma proteins bound readily to IC-21 Fc-receptors, the former in nonaggregated as well as aggregated form, the latter only as aggregated complexes. Thus, IgG2a bound in a manner characteristic of classically defined cytophilic antibody, whereas the binding of IgG2b appeared to be mediated by Fc-receptors for antigen-antibody complexes. Evidence is presented in support of the view that IC-21 macrophages possess separate and distinct Fc-receptor sites for these two immunoglobulins.
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