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  • Title: Efficacy of inhaled corticosteroids administered once daily for asthma.
    Author: Self TH, Sameri RM.
    Journal: Am J Manag Care; 2003 Jan; 9(1):91-9; quiz 100-2. PubMed ID: 12549817.
    Abstract:
    Inhaled corticosteroids (ICS) are the most effective medications for the long term control of asthma. When first used in asthma management, these drugs were scheduled 3- or 4-times daily, but by the late 1980s, it became clear that most patients respond excellently to twice-daily dosing. Numerous recent double-blind, randomized trials have demonstrated the efficacy of once-daily ICS in the management of pediatric and adult asthma. Once-daily dose ICS is most appropriate for patients' mild persistent asthma, and will be effective for many patients with moderate persistent asthma. Some studies suggest late afternoon/early evening dosing is preferable to single daily dosing in the morning.
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