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  • Title: Evidence for the role of a trypsin-like enzyme in the hamster sperm acrosome reaction.
    Author: Meizel S, Lui CW.
    Journal: J Exp Zool; 1976 Jan; 195(1):137-44. PubMed ID: 1255118.
    Abstract:
    Acrosome reactions occurring in vitro in hamster sperm capacitated by bovine follicular fluid were severly inhibited by four synthetic trypsin inhibitors and by Zn2+. Three polypeptide trypsin inhibitors and a synthetic chymotrypsin inhibitor did not inhibit the acrosome reaction, and Ca2+ overcame the inhibition by Zn2+. These results suggest that a trypsin-like enzyme (possibly acrosin) plays a role in the acrosome reaction.
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