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  • Title: Prognostic value of glucose transporter 1 expression in patients with hypopharyngeal carcinoma.
    Author: Mineta H, Miura K, Takebayashi S, Misawa K, Araki K, Misawa Y, Ueda Y.
    Journal: Anticancer Res; 2002; 22(6B):3489-94. PubMed ID: 12552944.
    Abstract:
    BACKGROUND: The increase of glucose transport is a distinguishing marker of tumor cells. We hypothesized that a hypopharyngeal carcinoma, characterized by high frequency of lymph node spread or distant metastasis, was associated with glucose transporter 1 (Glut 1) overexpression. MATERIALS AND METHODS: We investigated the incidence of Glut1 expression by immunostaining in 99 patients with hypopharyngeal carcinoma, and revealed the correlation with the clinical characteristics. RESULTS: The analysis showed 46 patients (46%) of Glut1 overexpression (> 70% tumor cell stained). Glut1 expression did not correlate with gender, subsite, histological grade, tumor size, lymph node status or stage grouping. The 5-year relapse-free survival (RFS) rate of patients with Glut1 overexpression (> 70%) (35%) was significantly lower than that of patients with low Glut1 expression (< or = 70%) (57%) (p = 0.047). Multivariate analysis showed that advanced tumor stage (stages III and IV) and Glut1 overexpression were predictors of reduced RFS (p = 0.031 and 0.021, respectively). CONCLUSION: Glut1 expression is an indicator for predicting the prognosis of hypopharyngeal carcinoma.
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