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  • Title: [Hepatitis B--a viral oncogene?].
    Author: Weis NM, Krogsgaard K.
    Journal: Ugeskr Laeger; 2002 Dec 09; 164(50):5940-4. PubMed ID: 12553116.
    Abstract:
    Infection with hepatitis B virus may develop into a chronic carrier state, which may result in chronic hepatitis, cirrhosis and hepatocellular carcinoma, but the exact mechanism of the development of hepatocellular carcinoma is still not known. The question is whether it is hepatitis B virus itself or the cellular changes due to persistent hepatitis B virus infection that cause malignant changes? The purpose of this article was to describe the natural history of hepatitis B virus infection together with epidemiological, serological, and molecular data that show a connection between chronic hepatitis B virus infection and the development of hepatocellular carcinoma.
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