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  • Title: Localization of c-Fos protein in the rat spinal cord after carrageenan treatment.
    Author: Jergová S, Cízková D, Orendácová J, Cízek M, Marsala J.
    Journal: Acta Histochem; 2002; 104(4):381-5. PubMed ID: 12553707.
    Abstract:
    We have characterized segmental and laminar distribution patterns of Fos-immunopositive (Fos-IP) neurons in spinal cord segments L3-L6 after carrageenan treatment. A large number of Fos-IP neurons was found in the medial region of the ipsilateral dorsal horn laminae I-II at 4 and 6 h postinjection (pi). At one day pi, the number of Fos-IP neurons was decreased significantly, which correlated with suppression of inflammation in the affected hind paw. Bilaterally, Fos-IP neurons reappeared in the L3-L6 spinal cord segments at 3-4 days pi, mainly in the deep laminae LV-LVI. However, signs of inflammation had distinctly attenuated. Our data indicate a biphasic trend in Fos-IP in this experimental model of inflammation.
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