These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Gp130-mediated pathway and left ventricular remodeling.
    Author: Yamauchi-Takihara K.
    Journal: J Card Fail; 2002 Dec; 8(6 Suppl):S374-8. PubMed ID: 12555148.
    Abstract:
    The binding of ligands to gp130 activates the JAK/STAT pathway, where STAT3 plays a central role in transmitting signals from the membrane to the nucleus. Cardiac-specific disruption of gp130 was shown to present heart failure in response to mechanical stress accompanied by an increase in apoptosis. Thus, the inactivation of STAT3 resulting from the loss of gp130 may be a key event in the transition from cardiac hypertrophy to heart failure. Vascular formation mediated by VEGF is known to be an essential in the maintenance of cardiac function. In this review, STAT3 is highlighted as a regulator of antiogenic factors, and together with bclxL and MnSOD, promotes cardiac myocyte survival by prevention of apoptosis and restoration of energy deprivation. Cytoprotective signal through gp130 would provide new insight into the pathophysiologic significance of cytokines in the process of cardiac remodeling.
    [Abstract] [Full Text] [Related] [New Search]