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  • Title: Hypoxia-like tissue injury as a component of multiple sclerosis lesions.
    Author: Lassmann H.
    Journal: J Neurol Sci; 2003 Feb 15; 206(2):187-91. PubMed ID: 12559509.
    Abstract:
    Recent data suggest that the mechanisms of demyelination and tissue damage in multiple sclerosis (MS) are heterogenous. In this review, evidence is discussed, which show that in a subset of multiple sclerosis patients the central nervous system (CNS) lesions show profound similarities to tissue alterations found in acute white matter stroke, thus suggesting that a hypoxia-like metabolic injury is a pathogenetic component in a subset of inflammatory brain lesions. Both, vascular pathology as well as metabolic disturbances induced by toxins of activated macrophages and microglia may be responsible for such lesions in multiple sclerosis.
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