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  • Title: [Immunohistological observation of tonsillae in IgA nephropathy].
    Author: Zhou M, Zhou WG, Yin HL.
    Journal: Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2000 Dec; 14(12):536-7. PubMed ID: 12563949.
    Abstract:
    OBJECTIVE: To realize the relationship between IgA nephropathy (IgA-N) and immunological abnormality of tonsillae. METHOD: Thirty-one patients were diagnosed as IgA-N via renal puncture. Sixteen patients suffering from chronic tonsillitis as control. All resected tonsillae were labelled immunohistologically by ABC method. RESULT: The differences of expression of IgA, IgG in the tonsillae between above two groups were significantly obvious. The number of lymphocytes which can produce IgA increased in IgA-N tonsillae. CONCLUSION: The immune functions are abnormal in IgA-N patients. Tonsillectomy can prevent the antigen invasion, eliminate IgA originated from tonsillae, decrease the IgA immunocomplex in circulation, therefore decrease the IgA immunocomplex deposition in the basal membrane of glomeruli.
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