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  • Title: Impact of posterior GPI pallidotomy on leg tremor in Parkinson's disease.
    Author: Goto S, Nishikawa S, Mita S, Ushio Y.
    Journal: Stereotact Funct Neurosurg; 2002; 78(2):64-9. PubMed ID: 12566832.
    Abstract:
    Although stereotactic thalamotomy is the mainstay in the surgical treatment of tremor in patients with Parkinson's disease (PD), this surgery is not favored and is even a matter of potential concern in the treatment of leg tremor since it carries a significant risk of injury to the internal capsule. In this study we have carried out a quantitative assessment of leg tremor alleviation in 12 patients with PD after MRI-/microelectrode-guided stereotactic ablation of the posterior part of the globus pallidus internus (GPi). The results showed that posterior GPi pallidotomy combined with drug therapy is a satisfactorily effective therapeutic strategy to treat parkinsonian leg tremor.
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