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  • Title: Polymeric proanthocyanidins from the bark of Hamamelis virginiana.
    Author: Dauer A, Rimpler H, Hensel A.
    Journal: Planta Med; 2003 Jan; 69(1):89-91. PubMed ID: 12567291.
    Abstract:
    Polymeric proanthocyanidins were isolated from the bark of Hamamelis virginiana L. in yields of about 5 %. Fractionation yielded fractions with similar structures but different molecular weights with DP between 17-29 (thiolysis) and 11-20 (GPC). Polymers were composed predominantly of epicatechin and epigallocatechin as chain extension units at ratio of about 1.3:1. Terminal chain units were catechin (approximately 95 %) and gallocatechin (approximately 5 %). All chain extension units were completely galloylated at position O-3, while chain terminating units were not galloylated. Predominant interflavan linkages were 4 --> 8-bonds.
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