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  • Title: [The diagnostic value of combined detection of circulating antigens and antibodies in urine of patients with schistosomiasis japonica].
    Author: Zhang EY, Lou WX, Xue CL, Wang ZJ.
    Journal: Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi; 2000; 18(1):24-5. PubMed ID: 12567466.
    Abstract:
    OBJECTIVE: To assess the value of detecting circulating antigens and antibodies in urine as a noninvasive method for the diagnosis of schistosomiasis. METHODS: A sandwich ELISA and ELISA using McAb were applied to detect circulating schistosomal antigens and specific antibodies in the urine of patients with acute and chronic schistosomiasis. RESULTS: When the urine samples from 10 cases of acute schistosomiasis and 61 cases of chronic schistosomiasis were examined, the positive rates of circulating antigens and specific antibodies were 60%, 40%, and 80%, 60.1%, respectively; when both detection was combined, the positive rates were 100% and 71.7% respectively, whereas a false positive rate of 3% of CAg or CAb was detected in the urine of 100 normal controls. CONCLUSION: The detection of circulating antigen in urine is a practicable and noninvasive method for the diagnosis of schistosomiasis.
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