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  • Title: [Effect of artemether on enzymes involved in carbohydrate metabolism of Schistosoma japonicum].
    Author: Zhai ZL, Zhang Y, Liu HX, Feng T, Xiao SH.
    Journal: Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi; 2000; 18(3):162-4. PubMed ID: 12567696.
    Abstract:
    OBJECTIVE: To study the effect of artemether on several enzymes involved in carbohydrate metabolism of Schistosoma japonicum. METHODS: Mice infected with Schistosoma japonicum cercariae for 4-5 weeks were administered intragastrically with artemether 300 mg/kg and killed 24-72 h after medication. The supernatant fluids of female and male worm homogenates were prepared for determining 9 essential enzymes of carbohydrate metabolism by using horizontal starchgel electrophoresis. RESULTS: The activities of 8 out of 9 enzymes (i.e. hexokinase, aldolase, glucosephophate isomerase, malate dehydrogenase, malic enzyme, glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and mannose-6-phosphate isomerase) in female worms from artemether-treated mice were obviously inhibited 24-72 h after treatment. In male worms, only aldolase, mannose-6-phosphate isomerase and glucose 6-phosphate dehydrogenase were slightly inhibited. CONCLUSION: Artemether displayed apparent effects on the carbohydrate metabolism of female schistosomes.
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