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  • Title: [Susceptibility and immune responses to Pneumocystis carinii infection in different strains of mice by contagious transmission].
    Author: An CL, Su XP, Harmsen AG.
    Journal: Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi; 2002; 20(4):220-2. PubMed ID: 12568024.
    Abstract:
    OBJECTIVE: To explore the susceptibility of different strains of mice to P. carinii infection and the host immune response to the organism. METHODS: C57BL/6 and BALB/c strains of mice (15 each) were exposed to SCID mice infected with P. carinii by co-housing. Observations were made on the number of parasites in the lungs, level of CD4+ T cell and CD8+ T cell in BALF, and serum IgG at 4, 5 and 6 wk after contagion. RESULTS: The number of P. carinii grew in the lungs of BALB/c mice was found much greater than those in C57BL/6 mice. A few number of P. carinii cysts were detected in the lungs of both strains of mice by 4 wk after co-housing, the number of cysts increased at 5 wk in the lungs of BALB/c mice but not in that of C57BL/6 mice. P. carinii-specific IgG in the sera and high level of CD62low CD4- and CD8-positive T cells in the lungs were found at 5 wk. The parasites were cleared from the lungs at 6 wk in all infected mice, shortly after acquired immune response was initiated. CONCLUSION: BALB/c mice are more susceptible to P. carinii than the C57BL/6 mice by natural transmission, and all the immunocompetent mice can clear the infection of P. carinii by cellular and humoral immune responses.
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