These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [C677T genetic polymorphism of methylenetetrahydrofolate reductase in premature coronary heart disease].
    Author: Xu H, Chen Z, Tang J, Zhu D, Zhang C.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 1999 Apr; 21(2):118-21. PubMed ID: 12569666.
    Abstract:
    OBJECTIVE: Methylenetetrahydrofolate reductase (MTHFR) is an important factor responsible for hyperhomocysteinemia. The relation of MTHFR gene C677T polymorphism and premature coronary heart disease was studied. METHODS: MTHFR C677T genetic polymorphisms in 67 patients with premature coronary heart disease were detected by PCR-RFLP technique. RESULTS: In case group, the frequency of T homogenic type was 34.3% (23/67), heterogenic type 43.3% (29/67) and C homogenic type 22.4% (15/67). T allele frequency was 55.9% (75/134) while C allele frequency 44.1% (59/134) in case group. There were significant differences in MTHFR genotype and allele frequencies between cases and controls (chi 2 = 6.82 and 5.41 respectively, P < 0.05). CONCLUSIONS: It was suggested that MTHFR gene C677T mutation was a possible risk factor of Chinese premature coronary heart disease.
    [Abstract] [Full Text] [Related] [New Search]