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  • Title: [The activity of the dehydrogenases of the tricarboxylic acid cycle and concentration of adenylic nucleotides in the brain and liver in experimental hypothyroidism].
    Author: Glushakova NE, Misiuk EM, Taranovich GL.
    Journal: Probl Endokrinol (Mosk); 1976; 22(1):50-4. PubMed ID: 1257219.
    Abstract:
    A determination was made of the activity of the cycle of tricarbolic acids of dehydrogenases and of the content of adeninnucleotides in the brain and the liver of rats in experimental hypothyroidism caused by mercasolyl administration. There were revealed deviations in the activity of dehydrogenases, more pronounced in the liver. Adeninnucleotide content was found to be reduced only in the brain. ATP/ADP ratio decreased in both tissues. The data obtained are discussed with consideration to the possibility of allosteric regulation of the enzyme activity and peculiarities attending the metabolism of substances in the tissues under study.
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