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  • Title: [The effect of insulin on amino acid accumulation and their incorporation into the proteins of incubated rat diaphragm. The effect of preliminary hypophysectomy and experimental diabetes].
    Author: Sadovnikova NV, Fedotov VP.
    Journal: Probl Endokrinol (Mosk); 1976; 22(1):54-9. PubMed ID: 1257220.
    Abstract:
    A study was made of the effect of insulin on some indices of protein metabolism in the incubated muscle of the diaphragm obtained from intact rats, hypophysectomized animals, rats with alloxan diabetes and animals with a combined functional exclusion of the hypophysis and the pancreas. Preliminary hypophysectomy depressed and alloxan diabetes increased the effect of insulin on leucin-C14 incorporation into the protein of the diaphragm. At the same time both preliminary actions promoted an increase of sensitivity of the incubated diaphragm to insulin as seen in examination of accumulation of H3-alphaaminoisobutyric acid. Combined exclusion of the function of the hypophysis and the pancreas led to less pronounced changes in the sensitivity of the diaphragm to insulin than each of the actions separately.
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