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  • Title: Randomized controlled trial of laparoscopic versus open colectomy for advanced colorectal cancer.
    Author: Hasegawa H, Kabeshima Y, Watanabe M, Yamamoto S, Kitajima M.
    Journal: Surg Endosc; 2003 Apr; 17(4):636-40. PubMed ID: 12574925.
    Abstract:
    BACKGROUND: After confirming a favorable outcome of laparoscopic surgery for early colorectal cancer, we conducted a randomized controlled trial to compare short-term outcomes of laparoscopic and open colectomy for advanced colorectal cancer. METHODS: Fifty-nine patients with T2 or T3 colorectal cancer were randomized to undergo laparoscopic (n = 29) or open (n = 30) colectomy. Median follow-up was 20 months (range, 6-34 months). RESULTS: Operative time was longer (p <0.0001) and blood loss (p = 0.0034) and postoperative analgesic requirement were less in the laparoscopic group than in the open group. An earlier return of bowel motility and earlier discharge from the hospital (p = 0.0164) were observed after laparoscopic surgery. Serum C-reactive protein levels on postoperative days 1 (p <0.0001) and 4 (p = 0.0039) were lower in the laparoscopic group than in the open group. Postoperative complications did not differ between the two groups. CONCLUSION: Laparoscopic surgery for advanced colorectal cancer is feasible, with favorable short-term outcome.
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