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  • Title: [Value of simultaneous determination of serum hyaluronic acid, collagen type IV and the laminin level in diagnosing liver fibrosis].
    Author: Liang XH, Zheng H.
    Journal: Hunan Yi Ke Da Xue Xue Bao; 2002 Feb 28; 27(1):67-8. PubMed ID: 12575242.
    Abstract:
    OBJECTIVE: To study the value of simultaneous determination of serum hyaluronic acid(HA), collagen Type IV (CIV) and the laminin (LN) level in the diagnosis of liver fibrosis. METHODS: Serum HA, CIV and LN were measured by ELISA in 22 healthy persons, 10 cases of acute hepatitis, 10 cases of chronic hepatitis, 10 cases of heary chronic hepatitis, and another 25 cases of posthepatitic cirrhosis. The sensitivity, specificity and accuracy of simultaneous determination were compared with those of single determination in posthepatitic cirrhosis. RESULTS: The levels of serum HA, CIV and LN in posthepatitic cirrhosis cases and heary chronic hepatitis cases were significantly higher than those in the other groups (P < 0.01). Simultaneous determination of these indices enhanced the diagnostic sensitivity, but decreased the diagnostic specificity. CONCLUSION: Simultaneous determination of HA, CIV and LN can enhance the diagnostic sensitivity. Simultaneous determination of HA and CIV is an optimal choice.
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