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  • Title: [Effects of vasoactive intestinal peptide on the enzyme activity of CTP: phosphorylcholine cytidylyltransferase from the rat lung].
    Author: Guan CX, Zhou FW, Luo ZQ.
    Journal: Hunan Yi Ke Da Xue Xue Bao; 2002 Apr 28; 27(2):99-101. PubMed ID: 12575328.
    Abstract:
    OBJECTIVE: To investigate the effect of vasoactive intestinal peptide(VIP) on the microsomal CTP: phosphorylcholine cytidylyltransferase activity of cultured lung explants and its mechanisms. METHODS: The CDP-[M-14 C] choline content reflecting the microsomal CTP: phosphorylcholine cytidylyltransferase activity of cultured lung explants was measured with liquid scintillation. RESULTS: 1. VIP increased the microsomal CTP: phosphorylcholine cytidylyltransferase activity of cultured lung explants in a dose-dependence manner and in a time-dependence fashion; 2. The effect of 3 x 10(-7) mol.L-1 VIP on the microsomal CTP: phosphorylcholine cytidylyltransferase activity of cultured lung explants was inhibited by H-7, a protein kinase C(PKC) inhibitor and W-7, a calmodulin antagonist respectively. CONCLUSION: VIP in the lung may be one of the key regulators involved in the synthesis of phosphatidylcholine mediated by PKC and calmodulin.
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