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  • Title: [Adrenocortical tumors with neuroendocrine differentiation].
    Author: Kazantseva IA, Poliakova GA, Gurevich LG, Morozov IA, Bezuglova TV, Smirnov VB.
    Journal: Arkh Patol; 2002; 64(5):8-13. PubMed ID: 12575533.
    Abstract:
    18 adrenocortical tumours and 5 pheochromocytomas were studied immunohistochemically. Expression of synaptophysin and chromogranin A was found in cells of cortical adenomas, "frontier" neoplasms and in 20-75% of carcinoma cells, this ultramicroscopically was confirmed by observation of typical neuroendocrine granules. Some groups of cells of cortico-medullary tumours also expressed proteins of neural differentiation (protein S-100).
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