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  • Title: Lysosome-related organelles: a view from immunity and pigmentation.
    Author: Raposo G, Fevrier B, Stoorvogel W, Marks MS.
    Journal: Cell Struct Funct; 2002 Dec; 27(6):443-56. PubMed ID: 12576637.
    Abstract:
    Lysosomes are ubiquitous organelles that carry out essential household functions. Certain cell types, however, contain lysosome-related organelles with specialized functions. Their specialized functions are usually reflected by specific morphological and compositional features. A number of diseases that develop due to genetic mutations, pathogen exposure or cell transformation are characterized by dysfunctional lysosomes and/or lysosome-related organelles. In this review we highlight adaptations and malfunction of the endosomal/lysosomal system in normal and pathological situations with special focus on MHC class II compartments in antigen presenting cells and melanosomes in pigment cells.
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