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  • Title: Metastatic breast carcinoma presenting as a large pulmonary embolus: case report and review of the literature.
    Author: Geschwind JF, Dagli MS, Vogel-Claussen J, Seifter E, Huncharek MS.
    Journal: Am J Clin Oncol; 2003 Feb; 26(1):89-91. PubMed ID: 12576931.
    Abstract:
    Involvement of the pulmonary vasculature by carcinoma of the breast typically occurs in the form of microscopic tumor emboli involving the small arteries, arterioles, or capillaries. Obstruction of a large pulmonary artery by a tumor embolus has not been reported. We describe a patient with a history of breast carcinoma diagnosed 5 years previously who sought treatment for dyspnea and a large mass in the right pulmonary artery suggestive of a pulmonary embolus. After failure of both systemic and intraarterial thrombolytic therapy, a biopsy of the mass was obtained, which revealed adenocarcinoma of the breast. Systemic chemotherapy with doxorubicin and cyclophosphamide was initiated and resulted in the complete resolution of her symptoms.
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