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  • Title: A metabolic approach to the evaluation of peripheral vascular disease.
    Author: O'Donnel TF, Clowes GH, Browse NL, Ryan NT, Blackburn GL.
    Journal: Surg Gynecol Obstet; 1977 Jan; 144(1):51-7. PubMed ID: 12579.
    Abstract:
    Thirty-five patients with occlusive disease of the arteries underwent metabolic studies. The arteriovenous differences of lactate, glucose and oxygen varied with the severity of the ischemic process, as assessed clinically. Lactate release and glucose extraction were significantly different from control values of patients with rest pain or with ischemic gangrene, while values in patients with claudication were comparable with those in the control group. Percutaneous muscle surface pH measurements, which reflect lactate release, decreased directly with diminished perfusion. Metabolic assessment of arterial occlusive disease may prove to be a useful clinical approach.
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